Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy
Mesenchymal stem cells (MSCs) are promising candidates for cell-based therapies. Human platelet
lysate represents an efficient alternative to fetal bovine serum for clinical-scale expansion of MSCs. Different media
used in culture processes should maintain the biological characteristics of MSCs during multiple passages. However,
bone marrow-derived MSCs and adipose tissue-derived MSCs have not yet been directly compared with each other
under human platelet lysate conditions. This study aims to conduct a direct head-to-head comparison of the biological
characteristics of the two types of MSCs under human platelet lysate-supplemented culture conditions for their ability
to be used in regenerative medicine applications.